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Volume 34 , Issue 5
September/October 2014
Pages 611–620

Radiographic Comparison of Different Concentrations of Recombinant Human Bone Morphogenetic Protein with Allogenic Bone Compared with the Use of 100% Mineralized Cancellous Bone Allograft in Maxillary Sinus Grafting

Stuart J. Froum, DDS/Stephen Wallace, DDS/Sang-Choon Cho, DDS/Ismael Khouly, DDS, MS, PhD/Edwin Rosenberg, DMD/Patricia Corby, DDS, MS/Scott Froum, DDS/Patrick Mascarenhas, DDS/Dennis P. Tarnow, DDS

PMID: 25171031
DOI: 10.11607/prd.2037

The purpose of this study was to radiographically evaluate, then analyze, bone height, volume, and density with reference to percentage of vital bone after maxillary sinuses were grafted using two different doses of recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and a control sinus grafted with MCBA only. A total of 18 patients (36 sinuses) were used for analysis of height and volume measurements, having two of three graft combinations (one in each sinus): (1) control, MCBA only; (2) test 1, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); and (3) test 2, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). The study was completed with 16 patients who also had bilateral cores removed 6 to 9 months following sinus augmentation. A computer software system was used to evaluate 36 computed tomography scans. Two time points where selected for measurements of height: The results indicated that height of the grafted sinus was significantly greater in the treatment groups compared with the control. However, by the second time point, there were no statistically significant differences. Three weeks postsurgery bone volume measurements showed similar statistically significant differences between test and controls. However, prior to core removal, test group 1 with the greater dose of rhBMP-2 showed a statistically significant greater increase compared with test group 2 and the control. There was no statistically significant difference between the latter two groups. All three groups had similar volume and shrinkage. Density measurements varied from the above results, with the control showing statistically significant greater density at both time points. By contrast, the density increase over time in both rhBMP groups was similar and statistically higher than in the control group. There were strong associations between height and volume in all groups and between volume and new vital bone only in the control group. There were no statistically significant relationships observed between height and bone density or between volume and bone density for any parameter measured. More cases and monitoring of the future survival of implants placed in these augmented sinuses are needed to verify these results. (Int J Periodontics Restorative Dent 2014;34:611–620. doi: 10.11607/prd.2037)

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